Fig. 1.

Ectopic expression of Brd4 positively regulates cell invasion and migration. (A) Four separate clonal isolates of Mvt-1/Brd4 and Mvt-1/β-Gal cells were grown on the top of a solidified basement membrane extract. Both the invasive properties and the ability to form cell extensions were significantly reduced in the Brd4 cells compared with the control cells. (B and C) Matrigel invasion and transwell migration assays of the four clonal isolates of Mvt-1/Brd4 and Mvt-1/β-Gal cells. Both the invasion and the migration properties of the Mvt-1 cells were reduced by ectopic expression of Brd4.