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. 2008 Apr 23;105(17):6415–6420. doi: 10.1073/pnas.0710263105

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© 2008 by The National Academy of Sciences of the USA

Freely available online through the PNAS open access option.

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Fig. 1. — Changes in miRNA levels in sporadic AD brain. (A) Significantly changed miRNAs in cortex of sporadic AD cases. Differences (fold change, compared with controls group), P values, and chromosome localization of miRNA genes are shown. miRNAs predicted to target BACE1 and/or APP 3′UTRs identified by various algorithms: miRanda (www.microrna.org), Targetscan (targetscan.org), Pictar (pictar.bio.nyu.edu), and miRbase (http://microrna.sanger.ac.uk) are highlighted in gray. (B) Conservation plot of human BACE1 and APP 3′UTRs with putative miRNA binding sites. The percentage of conservation in four mammalian species (human, mouse, rat, and dog) is shown. bp, base pairs.