Table 1.
Physiologic parameters of rats measured by blood gas analysis and in vivo 31P MRS under four anesthesia conditions
| Anesthesia condition | pCO2, mm Hg | pO2, mm Hg | CGlc, mg/dl | ABP, mm Hg | HR, beats per min | pH |
|
|---|---|---|---|---|---|---|---|
| Blood | Tissue | ||||||
| IsoF | 33.4 ± 2.9 | 141.5 ± 36.3 | 162.3 ± 14.4 | 103 ± 7 | 370 ± 25 | 7.49 ± 0.03 | 7.15 ± 0.01 |
| α-Ch | 31.0 ± 3.0 | 155.2 ± 20.2 | 112.0 ± 12.4* | 108 ± 10 | 350 ± 33 | 7.43 ± 0.06 | 7.15 ± 0.02 |
| Low-Pen | 30.6 ± 2.8 | 131.6 ± 28.3 | 95.5 ± 15.3* | 104 ± 13 | 394 ± 16 | 7.48 ± 0.05 | 7.16 ± 0.01 |
| High-Pen | 29.6 ± 4.8 | 156.0 ± 34.9 | 53.0 ± 6.0* | 64 ± 6* | 300 ± 14* | 7.36 ± 0.03* | 7.15 ± 0.04 |
The results were averaged from two blood samples collected before and after in vivo 31P MT or EEG experiments under each physiological condition. The pH values of brain tissue were measured according to pH = 6.75 + log[(δ − 3.26)/(5.70 − δ)], where δ is the chemical shift difference between the Pi and PCr resonances. ABP, arterial blood pressure; HR, heart beating rate; CGlc, blood glucose concentration.
*The measured parameter was statistically significant different (P < 0.05 with unpaired two-tailed t test) from that measured under the IsoF condition.