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Basal blood pressure of KO and WT mice. Day time (light period), night time (dark period) and 24-hour average systolic (A) and diastolic (B) blood pressure in mice (n = 6 per genotype). BP showed normal diurnal pattern in both genotypes. KO mice had significantly higher systolic blood pressure. *, a mean is significantly different (P < 0.05) from that of the WT by unpaired t test.
