Table 2.
Tumor sample data
| Sample | M4 | M4 T/N | MDM4-S/flM4 | MDM4-211 | MDM4-211 to flM4 | M2 T/N | M4 to M2 | TP53 status | BRAF mut | Ret/PTC rearr. | Patient statusa | Tumor stage | Multifocality | N1 | M1 | Histologyb |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 9.42 | 0.9 | 1.8 | 1.36 | 0.14 | 1 | 1.3 | wt | + | − | 1 | 3 | − | − | − | 2 |
| 2 | 18.96 | 1.3 | 5.2 | 1.4 | 2.5 | wt | − | − | 4 | 4 | + | + | + | 4 | ||
| 3 | 29.34 | 1.6 | 0.4 | 9.03 | 0.31 | 1.5 | 3.5 | wt | − | − | 1 | 1 | − | − | − | 2 |
| 4 | 14.93 | 1.7 | 9.7 | 1.1 | 2 | wt | − | + | 1 | 1 | + | − | − | 1 | ||
| 5 | 4.39 | 0.3 | 0.9 | 0.4 | 1.1 | wt | − | − | 4 | 4 | − | + | + | 3 | ||
| 6 | 11.16 | 0.4 | 1.3 | 0.5 | 1.9 | wt | − | − | 4 | 4 | − | + | + | 3 | ||
| 7 | 12.60 | 0.8 | 0.7 | 8.94 | 0.71 | 0.7 | 3.9 | wt | − | − | 1 | 1 | + | + | − | 1 |
| 8 | 4.44 | 0.4 | 0.8 | 2.1 | 0.7 | wt | + | − | n.d. | n.d. | − | − | n.d. | 1 | ||
| 9 | 15.51 | 1.4 | 0.6 | 1.4 | 1.6 | wt | + | − | 1 | 4 | + | + | − | 1 | ||
| 10 | 8.63 | 0.3 | 0.6 | 0.9 | 1.3 | wt | − | − | n.d. | n.d. | + | − | n.d. | 1 | ||
| 11 | 5.96 | 0.2 | 1.2 | 0.9 | 0.7 | wt | − | − | 2 | 4 | − | + | − | 1 | ||
| 12 | 8.11 | 0.5 | 1.1 | 1 | 0.9 | wt | + | − | 3 | 1 | + | + | − | 1 | ||
| 13 | 6.25 | 0.4 | 1.3 | 1 | 0.16 | 1.8 | 0.8 | wt | + | − | n.d. | n.d. | − | + | n.d. | 2 |
| 14 | 6.13 | 0.4 | 1.5 | 0.8 | 0.9 | wt | + | − | n.d. | n.d. | − | − | n.d. | 1 | ||
| 15 | 8.34 | 0.3 | 1.6 | 0.6 | 1.2 | wt | − | − | 1 | 1 | − | + | − | 1 | ||
| 16 | 3.82 | 0.2 | 1.4 | 1.23 | 0.32 | 0.8 | 0.5 | wt | + | − | 3 | 1 | − | − | − | 1 |
| 17 | 18.83 | 1 | 0.8 | 0.3 | 8.8 | wt | + | − | 2 | 4 | + | + | − | 2 | ||
| 18 | 6.32 | 1.2 | 0.7 | 1.1 | 1.2 | wt | + | − | 1 | 1 | − | − | − | 1 | ||
| 19 | 3.61 | 0.2 | 1.8 | 2.6 | 0.1 | wt | − | − | 1 | 1 | − | − | − | 2 | ||
| 20 | 5.12 | 0.3 | 3 | 0.9 | 0.8 | wt | + | − | n.d. | 1 | + | − | − | 1 | ||
| 21 | 8.4 | 0.5 | 4.2 | 0.6 | 1.1 | wt | − | + | 2 | n.d. | + | − | n.d. | 1 | ||
| 22 | 5.1 | 0.3 | n.d.* | 1 | 0.6 | wt | − | + | 1 | 3 | − | − | − | 1 | ||
| 23 | 7.06 | 0.9 | 0.9 | 2.6 | 0.7 | wt | + | − | n.d. | n.d. | − | − | n.d. | 1 | ||
| 24 | 8.85 | 0.6 | 0.1 | 1 | 1.4 | wt | + | − | 1 | 1 | + | − | − | 1 | ||
| 25 | 6.21 | 0.6 | 0.1 | 2.3 | 0.6 | wt | − | − | n.d. | n.d. | + | − | n.d. | 1 | ||
| 26 | 9.61 | 1 | 0.1 | 1.2 | 1.1 | wt | + | − | 1 | 1 | − | − | − | 2 | ||
| 27 | 7.11 | 0.3 | 0.6 | 0.4 | 1.6 | wt | + | − | n.d. | n.d. | + | + | n.d. | 1 | ||
| 28 | 3.53 | 0.2 | n.d. | 0.2 | 1.4 | wt | + | − | 1 | 2 | − | − | − | 2 | ||
| 29 | 5.76 | 0.4 | 2.2 | 0.7 | 1.2 | wt | + | − | n.d. | n.d. | + | − | n.d. | 1 | ||
| 30 | 10.7 | 1 | 1 | 1.9 | 1.2 | wt | + | − | 1 | 1 | − | − | − | 1 | ||
| 31 | 11.47 | 0.3 | n.d. | 0.8 | 0.9 | wt | − | + | 3 | 1 | + | + | − | 1 | ||
| 32 | 14.42 | 1.5 | n.d. | 2.4 | 1.4 | wt | + | − | 1 | 1 | − | − | − | 1 | ||
| 33 | 3.92 | 0.3 | 0.2 | 0.4 | 1.7 | wt | + | − | 3 | 4 | − | − | + | 1 | ||
| 34 | 11.96 | 0.7 | 1 | 0.5 | 2.8 | wt | − | − | 1 | 1 | − | − | − | 2 | ||
| 35 | 3.69 | 0.1 | 1.8 | 1.17 | 0.32 | 0.4 | 0.7 | wt | + | − | 1 | 4 | + | + | − | 2 |
| 36 | 8.03 | 0.4 | 2.7 | 0.7 | 1.4 | wt | + | − | 1 | 1 | − | − | − | 1 | ||
| 37 | 21.33 | 2 | 0.4 | 0.8 | 5.6 | wt | − | − | 1 | 1 | + | + | − | 4 | ||
| 38 | 5.56 | 0.4 | 4.7 | 1.6 | 0.6 | wt | + | − | 3 | 4 | + | + | − | 2 | ||
| 39 | 1.12 | 0.1 | 1.1 | 2.4 | 0 | wt | − | − | 1 | 4 | − | + | − | 2 | ||
| 40 | 13.98 | 1.4 | 1.4 | 3.5 | 0.9 | wt | + | − | 1 | 1 | + | − | − | 2 | ||
| 41 | 5.84 | 0.3 | 3.6 | 1 | 0.6 | wt | + | − | 3 | 4 | − | + | + | 1 | ||
| 42 | 7.36 | 0.3 | 1.3 | 1.83 | 0.25 | 0.9 | 0.8 | wt | + | − | 1 | 1 | − | − | − | 1 |
| 43 | 4.77 | 0.3 | 1.2 | 0.8 | 0.8 | wt | − | + | 3 | n.d. | − | + | n.d. | 4 | ||
| 44 | 2.45 | 0.1 | 2.2 | 0.7 | 0.4 | wt | + | − | 1 | 3 | − | + | − | 1 | ||
| 45 | 5.12 | 0.3 | 0.7 | 0.8 | 0.7 | wt | + | − | 3 | 4 | − | + | + | 1 | ||
| 46 | 3.1 | 0.3 | 2.1 | 1.6 | 0.2 | wt | + | − | 1 | 1 | − | − | − | 1 | ||
| 47 | 10.27 | 1.1 | 2.4 | 19.6 | 0.1 | wt | + | − | 1 | 1 | + | + | − | 2 | ||
| 48 | 12.13 | 1.1 | 2.4 | 1.1 | 2.2 | wt | + | − | n.d. | n.d. | + | − | n.d. | 1 | ||
| 49 | 7.94 | 0.8 | 1.6 | 0.8 | 2.2 | wt | − | − | 3 | 1 | + | + | − | 1 | ||
| 50 | 14.72 | 0.8 | 2.8 | 0.8 | 2.2 | wt | + | − | 3 | 4 | n.d. | + | − | 1 | ||
| 51 | 15.67 | 1 | 1 | 1 | 2.2 | wt | + | − | 1 | 2 | − | − | − | 1 | ||
| 52 | 66.49 | 3.6 | 0.6 | 3.6 | 2.2 | wt | + | − | 1 | n.d. | + | − | n.d. | 1 | ||
| 53 | 28.94 | 1.4 | 1.7 | 1.4 | 2.2 | wt | + | − | 1 | n.d. | − | − | n.d. | 1 | ||
| 54 | 3.72 | 0.4 | 0.3 | 2.8 | 0.5 | wt | − | − | 1 | n.d. | + | + | n.d. | 4 | ||
| 55 | 5.3 | 0.4 | 0.7 | 1.8 | 0.5 | wt | + | − | 1 | 1 | − | − | − | 1 | ||
| 56 | 2.04 | 0.6 | 0.9 | 2.3 | 0.3 | wt | n.d. | n.d. | 1 | n.d. | + | − | n.d. | 1 | ||
| 57 | 6.87 | 0.7 | n.d. | 1.4 | 0.8 | wt | n.d. | n.d. | 1 | n.d. | − | − | n.d. | 1 |
n.d. Not determined, N1 nodal metastasis, M1 distant metastasis
a1, recovered; 2, recurrence occurred, 3,disease persistence, 4, expired
b1, classic variant; 2, follicular variant; 3, dedifferentiated variant; 4, other