Figure 5.

Illustrating reactive animation in the lymph node model [SCH06]. In the top portion of the figure, the statechart transition from figure 4 that allows a B cell to differentiate to a plasma cell has been removed (top right) and as a result no plasma cells can be created. This can be seen in the animation snapshot (top left), which shows that B cells that were fated to become plasma cells (represented in the animation as yellow circles, secreting antibodies) stay undifferentiated (blue circles). In the bottom portion, the transition that allows receptor CXCR5 to be expressed has been removed (bottom right), thus preventing cells from expressing it. CXCR5 is necessary for cell migration as it responds to the chemokine signal BLC, which is secreted from the PF regions (primary follicles) and attracts cells to these regions. The animation snapshot shows that no cells are present in these areas (bottom left).