Table 1.
Genotype distribution of glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1 (GSTT1), and epoxide hydrolase 1 (EPHX1) in patients with chronic obstructive pulmonary disease and healthy controls in a sample of Slovak population*
| Genotype | No. (%) of |
OR (95% CI) for homozygous mutation | P | OR adjusted (95% CI) for homozygous mutation† | P | |
|---|---|---|---|---|---|---|
| COPD cases | controls | |||||
| GSTM1: | ||||||
| non-null genotype | 88 (40.6) | 75 (46.9) | ||||
| null genotype | 129 (59.4) | 85 (53.1) | 1.29 (0.84-1.99) | 0.221 | 1.34 (0.85-2.12) | 0.208 |
| GSTT1: | ||||||
| non-null genotype | 178 (82.0) | 129 (80.6) | ||||
| null genotype | 39 (18.0) | 31 (19.4) | 0.91 (0.52-1.60) | 0.729 | 0.91 (0.51-1.64) | 0.766 |
| EPHX1 exon 3 codon 113: | ||||||
| Tyr/Tyr | 105 (48.4) | 78 (48.8) | ||||
| Tyr/His | 70 (32.3) | 67 (41.9) | ||||
| His/His | 42 (19.3) | 15 (9.3) | 2.32 (1.20-4.69) | 0.008 | 1.79 (0.91-3.53) | 0.093 |
| EPHX1 exon 4 codon 139: | ||||||
| His/His | 140 (64.5) | 91 (56.9) | ||||
| His/Arg | 69 (31.8) | 63 (39.4) | ||||
| Arg/Arg | 8 (3.7) | 6 (3.7) | 0.98 (0.29-3.51) | 0.974 | 0.61 (0.20-1.90) | 0.393 |
*Abbreviations: COPD – chronic obstructive pulmonary disease; OR – odds ratio; CI – confidence interval.
†Adjusted for potential confounding factors (age, sex, and smoking status).