Table 1.
Gram-negative bacteria (GNB) resistant to aminoglycosides (gentamicin, amikacin, and netilmicin) in intensive care units in gentamicin and amikacin period
| GNB* | No. (%) of resistant isolates in: |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| gentamicin period |
amikacin period; P* |
||||||||||
| n† | gentamicin | amikacin | netilmicin | n† | gentamicin | P* | amikacin | P* | netilmicin | P* | |
| Proteus mirabilis | 36 | 10 (28) | 1 (2) | 8 (22) | 18 | 4 (22) | 0.030 | 1 (6) | >0.950 | 2 (11) | 0.014 |
| Enterobacter spp | 31 | 13 (42) | 6 (19) | 10 (32) | 26 | 8 (31) | 0.157 | 3 (12) | 0.317 | 7 (27) | 0.083 |
| Escherichia coli | 123 | 37 (30) | 32 (26) | 31 (25) | 75 | 10 (13) | <0.001 | 5 (7) | <0.001 | 4 (5) | <0.001 |
| Acinetobacter baumannii | 34 | 25 (73) | 6 (17) | 16 (48) | 24 | 14 (58) | 0.001 | 14 (58) | 0.014 | 10 (42) | 0.014 |
| Pseudomonas spp | 122 | 59 (48) | 45 (37) | 51 (42) | 62 | 23 (37) | <0.001 | 11 (18) | <0.001 | 22 (35) | <0.001 |
| Klebsiella spp | 78 | 24 (31) | 17 (22) | 20 (26) | 47 | 9 (19) | 0.083 | 5 (11) | 0.157 | 6 (13) | <0.001 |
| All GNB | 424 | 178 (42) | 85 (20) | 140 (33) | 252 | 66 (26) | <0.001 | 48 (19) | 0.456 | 50 (20) | <0.001 |
*Gentamicin vs amikacin period, z-test of proportions.
†n – number of isolates.