Table 3. Individual pharmacokinetic parameters of bendamustine in plasma.
| Subject | Dose (mg m−2 per day) | t1/2 (min) | tmax (min) | Cmax (ng ml−1) | AUCall (min ng ml−1) | AUCInf (min ng ml−1) | Vd (ml m−2) | Cl (ml min m−2) |
|---|---|---|---|---|---|---|---|---|
| 2 | 120 | 57.3 | 40 | 9011.5 | 490823.5 | 491145.7 | 24.3600 | 244.3 |
| 3 | 120 | 60.2 | 30 | 8907.3 | 540908.0 | 541672.9 | 19.2560 | 221.5 |
| 6 | 140 | 30.7 | 30 | 9978.4 | 437716.8 | 437991.4 | 14.1583 | 319.6 |
| 8 | 160 | 45.3 | 30 | 9966.1 | 448803.3 | 449333.0 | 23.2872 | 356.1 |
| 13 | 160 | 60.0 | 50 | 24474.6 | 1800220.3 | 1805225.4 | 7.6750 | 88.6 |
| 15 | 160 | 41.0 | 30 | 8797.7 | 444477.8 | 444631.4 | 21.2679 | 359.8 |
| Mean | 49.1 | 35.0 | 18.3341 | 265.0 | ||||
| s.d. | 12.1 | 8.4 | 6.3460 | 103.6 |
Abbreviations: AUCInf=AUC extrapolated to infinity; AUCall=area under the plasma concentration time curve from time of dosing to last observation; Cl=clearance; Cmax, maximum peak concentration; s.d.=standard deviation; t1/2=half life; tmax, time to reach peak concentration; Vd=volume of distribution.