Table 1. Relationship between clinicopathological variables and the VEGFRI mRNA expression in peripheral blood bone and marrow from gastric cancer cases.
VEGFR1 -bone marrow
|
VEGFR1 -peripheral blood
|
|||||||
---|---|---|---|---|---|---|---|---|
Positive
|
Negative
|
Positive
|
Negative
|
|||||
Features | n | (n=23) | (n=67) | P value | n | (n=34) | (n=56) | P-value |
Sex | ||||||||
Male | 61 | 16 | 45 | 0.83 | 61 | 26 | 35 | 0.17 |
Female | 29 | 7 | 22 | 29 | 8 | 21 | ||
Age (mean±s.d.) | 62.7±13.4 | 59.6±11.1 | 0.14 | 62.5±11.2 | 59.2±12 | 0.1 | ||
Stage | ||||||||
1 and 2 | 55 | 9 | 46 | <0.05 | 55 | 13 | 42 | <0.001 |
3 and 4 | 35 | 14 | 21 | 35 | 21 | 14 | ||
Invasion depth | ||||||||
Slighter than submucus | 28 | 4 | 24 | 0.09 | 28 | 5 | 23 | <0.01 |
Deeper than muscularis propria | 60 | 19 | 43 | 62 | 29 | 33 | ||
Lymphatic involvement | ||||||||
Negative | 58 | 10 | 48 | <0.05 | 58 | 14 | 44 | <0.001 |
Positive | 32 | 13 | 19 | 32 | 20 | 12 | ||
Vascular involvement | ||||||||
Negative | 65 | 14 | 51 | 0.16 | 65 | 16 | 49 | <0.0001 |
Positive | 25 | 9 | 16 | 25 | 18 | 7 | ||
Lymph node metastasis | ||||||||
Negative | 62 | 10 | 52 | <0.01 | 62 | 15 | 47 | <0.0001 |
Positive | 28 | 13 | 15 | 28 | 19 | 9 | ||
Peritoneal lavage cytology | ||||||||
Negative | 71 | 14 | 57 | <0.05 | 71 | 20 | 51 | <0.001 |
Positive | 19 | 9 | 10 | 19 | 14 | 5 | ||
Peritoneal dissemination | ||||||||
Negative | 82 | 20 | 62 | 0.42 | 82 | 30 | 52 | 0.46 |
Positive | 8 | 3 | 5 | 8 | 4 | 4 | ||
Perioperative overt metastasis | ||||||||
Negative | 72 | 16 | 56 | 0.15 | 72 | 23 | 49 | <0.05 |
Positive | 18 | 7 | 11 | 18 | 11 | 7 | ||
Postoperative recurrence | ||||||||
Negative | 78 | 16 | 62 | <0.01 | 78 | 25 | 53 | <0.01 |
Positive | 12 | 7 | 5 | 12 | 9 | 3 |
s.d.=standard deviation.