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. 2007 Apr 17;96(10):1526–1531. doi: 10.1038/sj.bjc.6603740

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Copyright © 2007 Cancer Research UK

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Effect of doxycycline treatment on bone histomorphometric parameters in a mouse bone metastasis model of human breast cancer (MDA-MB-231). Longitudinal sections of the femora were analysed to determine (A) eroded bone surface as a fraction of the trabecular bone surface (%), and (B) osteoid surface as a fraction of the trabecular bone surface (%), (C) number of osteoclasts per mm trabecular bone surface, and (D) number of osteoblasts per mm of trabecular bone surface. Data represent means±s.e. of the combined values of all animals in each of the groups in at least two separate experiments (n⩾3). ^* Significantly different from corresponding control group (no tumour cells injected) (P<0.05). ^** Significantly different from placebo control animals (no tumour cells injected) (P<0.05). ^oSignificantly different from placebo tumour-bearing animals (P<0.05). ^aSignificantly different from corresponding doxycycline-alone group (P<0.05). ^bSignificantly different from corresponding zoledronic acid-alone group (P<0.05).

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