Figure 3.
(A) Histological appearance of the left femur of a control mouse (untreated, no cell injections) stained with H&E. (B–E) Histological appearance of skeletal tumours in the left femora of mice injected with MDA-MB-231 cells after H&E staining. Mice were treated with (B) placebo, (C) doxycycline, (D) zoledronic acid, or (E) with both doxycycline and zoledronic acid. (Original magnification × 100, Bar = 150 μm). Bo, bone; GP, growth plate; Tu, tumour.