Table 2. HPV DNA detection in ESCC by PCR using SPF10 primers.
| All cases | HPV positive | HPV negative | ||
|---|---|---|---|---|
| N (%) | N (%) | N (%) | P-value* | |
| All | 59 (100%) | 19 (32%) | 40 (68%) | |
| Region | <0.001 | |||
| Shandong | 33 (100) | 2 (6) | 31 (94) | |
| Gansu | 26 (100) | 17 (65) | 9 (35) | |
| Gender | 1.000 | |||
| Male | 48 (100) | 16 (33) | 32 (67) | |
| Female | 11 (100) | 3 (33) | 8 (67) | |
| Age (years) a | 0.881 | |||
| <55 | 15 (100) | 4 (27) | 11 (73) | |
| 55–64 | 18 (100) | 6 (33) | 12 (67) | |
| ⩾65 | 25 (100) | 9 (36) | 16 (64) | |
| Differentiation grade | 0.008 | |||
| Well | 22 (100) | 2 (9) | 20 (91) | |
| Moderate | 22 (100) | 9 (41) | 13 (59) | |
| Poor | 15 (100) | 8 (53) | 7 (47) | |
| p16INK4a protein expression (%) | 0.160 | |||
| <10 | 40 (100) | 16 (40) | 24 (60) | |
| 10–79 | 9 (100) | 2 (22) | 7 (78) | |
| ⩾80 | 10 (100) | 1 (10) | 9 (90) | |
| p53 protein expression (%) | 0.813 | |||
| <10 | 28 (100) | 8 (29) | 20 (71) | |
| 10–79 | 11 (100) | 4 (36) | 7 (64) | |
| ⩾80 | 20 (100) | 7 (35) | 13 (65) |
*P-values were obtained by Fisher's exact test.
a
Information on age was missing in a case.