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. 2007 May 22;96(12):1871–1878. doi: 10.1038/sj.bjc.6603812

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Copyright © 2007 Cancer Research UK

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Ad/5HREp-BCD-mediated cytotoxicity. (A) HeLa, (B) MIA PaCa-2, and (C) WiDr cells were infected with the adenovirus, Ad/EFp-BCD or Ad/5HREp-BCD, and treated with various concentrations of 5-FC under normoxic (open) or hypoxic (solid) conditions. Cell viability was calculated as the ratio of the absorbance value under each of the conditions against that in medium with 0.1 mg ml⁻¹ of 5-FC under normoxic conditions. The same experiment was conducted with mock infection. Results are the mean±s.d. (n=3). ^*P<0.05. ^**P<0.01.