Table 2. Changes of pain intensity 15 and 30 min after treatment in all patients, and in patients using different ranges of basal opioid doses (<120, 120–270, and >330 mg of oral morphine equivalents, respectively).

	T0	T1	T2
OTFC	6.9 (6.6–7.2)	4.1 (3.5–4.7)	2.4 (1.8–2.9)
IV-MO	6.9 (6.6–7.2)	3.3 (2.7–3.8)*	1.7 (1.2–2.3)**
⩽120 mg of oral morphine equivalents
9 patients/14 events
OTFC	6.1 (5.4–6.7)	3.7 (2.5–4.8)	2.4 (1.0–3.8)
IV-MO	6.3 (5.8–6.8)	3.2 (2.2–4.3)	1.7 (0.5–3.0)
>120–270 mg of oral morphine equivalents
14 patients/33 events
OTFC	7.2 (6.8–7.5)	4.5 (3.7–5.3)	2.6 (1.8–3.3)
IV-MO	7.1 (6.6–7.5)	3.5 (2.8–4.2)	1.9 (1.2–2.7)
>330 mg of oral morphine equivalents
2 patients/6 events
OTFC	7.1 (6.6–7.6)	3.7 (2.3–5.1)	1.9 (0.6–3.2)
IV-MO	7.1 (6.3–7.8)	2.7 (1.4–4.1)	1.2 (0–2.6)

IV-MO=intravenous-morphine; OTFC=oral transmucosal fentanyl citrate.

Data are expressed as mean (95% CI). ^*P=0.013 and ^**P=0.059 (univariate repeated measures analysis ANOVA, F=6.694 and 3.732, respectively).