Table 2. List of individual studies with overall survival, bone metastasis-free survival and nonskeletal metastasis-free survival.

	HR (95% CI)
Study	Overall survival	Bone metastasis-free survival	Nonskeletal metastasis-free survival
Early breast cancer
Diel et al (1998)	0.26 (0.13, 0.55)	0.36 (0.18, 0.71)	0.38 (0.20, 0.72)
Powles et al (2002)	0.77 (0.59, 1.00)	0.69 (0.48, 0.99)	0.84 (0.62, 1.13)
Saarto et al (2001)	1.90 (1.17, 3.08)	1.26 (0.65, 2.46)	2.05 (1.25, 3.36)
Advanced breast cancer
Elomaa et al (1988)	0.27 (0.11, 0.66)	Not available	Not available
Kanis et al (1996)	0.92 (0.59, 1.42)	0.52 (0.27, 1.02)	Not available
Kristensen et al (1999)	0.99 (0.57, 1.73)	Not available	Not available
Mardiak et al (2000)	0.73 (0.38, 1.41)	2.11 (0.22, 20.34)	1.07 (0.41, 2.77)

CI=confidence interval; HR=hazard ratio.