Table 3. Relationship between tissue KLK6 status and other variables in ovarian cancer patients.
|
No. of patients (%)
|
||||
|---|---|---|---|---|
| Variable | Patients | KLK6 negativea | KLK6 positive | P-value |
| Stage | ||||
| I | 65 | 47 (72.3) | 18 (27.7) | <0.001b |
| II | 20 | 9 (45.0) | 11 (55.0) | |
| III | 143 | 62 (43.4) | 81 (56.6) | |
| IV | 18 | 4 (22.2) | 14 (77.8) | |
| xc | 13 | |||
| Grade | ||||
| G1 | 58 | 33 (56.9) | 25 (43.1) | 0.04b |
| G2 | 46 | 28 (60.9) | 18 (39.1) | |
| G3 | 139 | 59 (42.4) | 80 (57.6) | |
| xc | 16 | |||
| Histotype | ||||
| Serous | 110 | 39 (35.5) | 71 (64.5) | <0.001b |
| Endometrioid | 46 | 30 (65.2) | 16 (34.8) | |
| Mucinous | 20 | 14 (70.0) | 6 (30.0) | |
| Clear cell | 18 | 12 (66.7) | 6 (33.3) | |
| Undifferentiated | 33 | 10 (30.3) | 23 (69.7) | |
| Other nonepithelial | 24 | 20 (83.3) | 4 (16.7) | |
| xc | 8 | |||
| Debulking success d | ||||
| SD | 102 | 38 (37.3) | 64 (62.7) | 0.002e |
| OD | 140 | 80 (57.1) | 60 (42.9) | |
| xc | 17 | |||
| Response to CTX f | ||||
| NC/PD | 18 | 8 (44.4) | 10 (55.6) | 0.81b |
| PR | 41 | 19 (46.3) | 22 (53.7) | |
| CR | 180 | 91 (50.6) | 89 (49.4) | |
| NE | 20 | |||
a
Cutoff=2.83 μg mg−1 (50th percentile).
b
χ2 test.
c
Status unknown.
d
OD: optimal debulking (0–1 cm), SD: suboptimal debulking (>1 cm).
e
Fisher's exact test.
f
CTX=chemotherapy; NC=no change; PD=progressive disease; CR=complete response; PR=partial response; NE=not evaluated.