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. 2007 Jan 9;96(2):277–283. doi: 10.1038/sj.bjc.6603546

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Copyright © 2007 Cancer Research UK

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The pretreatment biopsy specimen (A–C) and the resected tumour (D) from a representative gastric cancer, which responded to neoadjuvant S-1/cisplatin chemotherapy. (A, D): HE staining, (B): TS immunoreactivity, (C): p53 immunoreactivity. Chemotherapy-induced histological changes including the disintegration of glandular structures with marked inflammatory cell infiltration is noted in the resected tumour when compared with the pretreatment biopsy specimen. The cytoplasm of only a few cancer cells (arrow) and plasma cells (arrowhead) in the stroma are positive for TS. There are no p53-positive cells.