Table 3. Relationship between expression of TS and p53, and effects of neoadjuvant S-1/cisplatin chemotherapy in surgically resected tumours.
| Marker expression | Histological responders (%)* (n=15) | Histological non-responders (%)** (n=26) | Control untreated cases (%)*** (n=51) |
P-value
|
||
|---|---|---|---|---|---|---|
| * vs ** | * vs *** | ** vs *** | ||||
| TS | ||||||
| High | 1 (7) | 7 (27) | 14 (27) | 0.22 | 0.16 | >0.99 |
| Low | 14 (93) | 19 (73) | 37 (73) | |||
| p53 | ||||||
| High | 1 (7) | 14 (54) | 15 (29) | <0.005a | 0.09 | <0.05a |
| Low | 14 (93) | 12 (46) | 36 (71) | |||
| TS- and/or p53-high | 1 (7) | 19 (73) | 26 (51) | <0.0001a | <0.005a | 0.09 |
| TS- and p53-low | 14 (93) | 7 (27) | 25 (49) | |||
a
Statistically significant.
*Responders, **Non-responders, ***Control cases.