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. 2007 Jan 23;96(2):383–390. doi: 10.1038/sj.bjc.6603555

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Copyright © 2007 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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Alpha-1B-adrenergic receptor promoter methylation was detected in four of 34 (11.8%) colorectal cancers and was not detected in surrounding colorectal epithelial tissues. Alpha-1B-adrenergic receptor promoter methylation was thus considered a cancer-specific event in colorectal cancers and surrounding epithelial tissues. In contrast, ADRA1B promoter methylation was detected in 24 of 34 (70.6%) gastric cancers and in 14 of 34 (41.2%) surrounding epithelial tissues. In gastric cancers, the frequency of ADRA1B promoter methylation increased progressively from Region 1 to Region 4. In surrounding epithelial tissues, the frequency of ADRA1B promoter methylation was also highest in Region 4.