Table 3. Genetics: the incidence of attributes used to define indications for referral for genetic assessment.

Population of interest	Attribute	Proportion of population with attribute	Reference	Quality of information
All registry cancers	Colorectal cancer	0.14	AIHW (2004)	α
Colorectal cancer	Family history	0.17	Fuchs et al (1994)	γ
CRC, family history	<55 years	0.38	Fuchs et al (1994)	γ
		0.14	St John et al (1993)	λ
CRC, family history, <55 years	Only one affected relative	0.93	St John et al (1993)	λ
CRC, family history, <55 years	Relative <50 years	0.21	St John et al (1993)	λ
Only one affected relative
CRC, no family history	<55 years	0.17	Kune et al (1989)	λ
CRC, no family history,<55	Family history of HNPCC related cancer	0.05	Slattery and Kerber (1994)	ζ
CRC, no family history	Proportion of patients with polyps	0.55	Boutron et al (1997)	λ
>55 years,
CRC, no family history	Proportion with multiple polyps	0.01	Muto et al (1975)	ε
>55, polyps			O'Brien et al (1990)
All registry cancers	Breast cancer	0.13	AIHW (2004)	α
Breast Cancer	Female	0.99	AIHW (2004)	α
Breast cancer, female	Family history in one 1° or 2° relative	0.22	Slattery and Kerber (1993)	ζ
	Family history in >one 1° relative	0.01
	Ovarian cancer in one 1° or 2° relative	0.03
Breast cancer, female	Age <50years	0.23	Slattery and Kerber (1993)	ζ
family history of breast cancer
Breast cancer, female	Relative <40years	0.15	CGHFBC (2001)	θ
family history of breast cancer,
age <50years
Breast cancer, female	Relative <40years	0.08	CGHFBC (2001)	θ
family history of breast cancer,
age >50years
Breast cancer, no family history	Age <50 years	0.19	Slattery and Kerber (1993)	ζ
All registry cancers	Ovarian cancer	0.01	AIHW (2004)	α
Ovarian cancer	Epithelial	0.9	AIHW (2004)	α
Ovarian cancer, epithelial	Relative with ovarian cancer	0.03	CGHFBC (2001)	ε
	Relative with breast cancer	0.06	Purdie et al (1995)
	Relative with bowel cancer	0.05
Ovarian cancer, epithelial	Relative <40 years	0.2	Easton et al (1996)	γ
Relative with breast cancer
Ovarian cancer, epithelial	Relative <50 years	0.13	Easton et al (1996)	γ
Relative with bowel cancer
All registry cancers	Prostate cancer	0.12	AIHW (2004)	α
Prostate cancer	>3 relatives over	0.07	Bratt et al (1999)	ε
	3 generations		Carter et al (1993)
			Keetch et al (1995)
All registry cancers	Melanoma	0.11	AIHW (2004)	α
Melanoma	Positive family history	0.1	Aitken et al (1994)	β
			Ang et al (1998)
All registry cancers	Lung cancer	0.1	AIHW (2004)	α
All registry cancers	Gynaecological cancers	0.04	AIHW (2004)	α
	excluding ovary
Gynaecological cancers	Endometrial cancer	0.56	AIHW (2004)	α
excluding ovary
Gynaecological cancers	Cervix	0.34	AIHW (2004)	α
excluding ovary	Vulva	0.07
	Vagina	0.03
Endometrial cancer	Family history	0.05	Boltenberg et al (1990)	θ
			Gruber and Thompson (1996); Sandles et al (1992)
All registry cancers	Head and neck cancer	0.04	AIHW (2004)	α
All registry cancers	Lymphoma	0.04	AIHW (2004)	α
All registry cancers	Unknown primary	0.04	AIHW (2004)	α
All registry cancers	Kidney cancer	0.03	AIHW (2004)	α
Kidney	Adenocarcinoma	0.8	AIHW (2004)	α
Kidney, adenocarcinoma	No family history	0.99	Czene and Hemminki (2002)	γ
Kidney, adenocarcinoma,	Multifocal or bilateral cancer	0.05	Neumann et al (1998)	ε
No family history
All registry cancers	Bladder cancer	0.03	AIHW (2004)	α
All registry cancers	Leukaemia	0.03	AIHW (2004)	α
All registry cancers	Gastric cancer	0.02	AIHW (2004)	α
All registry cancers	Pancreatic cancer	0.02	AIHW (2004)	α
Pancreatic	No family history	0.95	Silverman et al (1999)	ε
All registry cancers	Brain tumour	0.02	AIHW (2004)	α
Brain tumour	Haemangioblastoma	0.02		λ
All registry cancers	Soft tissue and bone	0.01	AIHW (2004)	α
Soft tissue and bone	<45 years	0.3	AIHW (2004)	α
Soft tissue and bone,	Family history of cancer	0.05
<45 years
Soft tissue and bone	Family history of breast or sarcoma	0.28	Moutou et al (1996)	λ
<45 years, family history
of cancer
Soft tissue and bone	Cancer in relative <45 years	0.17	Moutou et al (1996)	λ
<45 years,no family history
of cancer
All registry cancers	Thyroid	0.01	AIHW (2004)	α
Thyroid cancer	Papillary	0.72	Hundahl et al (1998)	γ
	Follicular	0.21
	Medullary	0.05
	Anaplastic	0.02
Medullary thyroid cancer	Familiy history	0.26	Moley et al (1998)	λ
All registry cancers	Liver cancer	0.01	AIHW (2004)	α
All registry cancers	Oesophagus	0.01	AIHW (2004)	α
All registry cancers	Gallbladder cancer	0.01	AIHW (2004)	α
All registry cancers	Myeloma	0.01	AIHW (2004)	α
All registry cancers	Testicular cancer	0.01	AIHW (2004)	α
All registry cancers	Other	0.01	AIHW (2004)	α