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. 2007 Jan 9;96(3):403–407. doi: 10.1038/sj.bjc.6603547

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Copyright © 2007 Cancer Research UK

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Hereditary leiomyomatosis and renal cell cancer pseudohypoxia. Fumarate accumulates due to loss of FH activity. Rising fumarate levels inhibit HPH with concomitant upregulation of hypoxia response genes including VEGF and GLUT-1.