Figure 3.

The relative nadir platelet count vs exposure to indisulam (A) and exposure to carboplatin (B). The solid lines represent the model predicted nadir counts after median exposure to carboplatin (6.7 mg min ml⁻¹) and varying exposure to indisulam (A) or after median exposure to indisulam (94 mg min ml⁻¹) and varying exposure to carboplatin (B). A plot of model predicted values vs the corresponding observed values (C) is symmetrically distributed around the line of unity, which demonstrates that the modified Hill equation resulted in unbiased predictions of the nadir platelet count. AUC, area under the plasma concentration vs time curve.