Table 3. Number of patients, DLTs, dose reductions per dose level.

Indisulam (mg m−2)	Carboplatin (mg min ml−1)	Number of patients treated	DLTs	Patients with dose reductions at cycle 2
350	6	4a	0	0
500	6	3	0	0
600	6	4	3 (75%)	2
600	5	5b	2 (50%)c	0

DLTs, dose limiting toxicities.

^aOne patient was not assessable for DLT, because he died due to progressive disease during cycle 1.

^bOne patient was not assessable for DLT, because she died due to progressive disease during cycle 1

^cTwo DLTs out of four assessable patients.