Table 2. Carboplatin doses and estimated renal function-based dosing AUC vs actual AUC following pharmacologically guided dosing.
Estimated
|
Achieved
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Study | Patient | GFR (ml min−1) | Target AUC (mg ml−1. min) | Dose modification | Estimated total dose (mg)a | Actual total dose (mg) | AUCb (mg ml−1.min) | % target AUC | AUC (mg ml−1.min) | % Target AUC |
MMT 98 | 1 | 110 | 20 | Day 3 | 2610 | 1653 | 30.3 | 152 | 19.6 | 98 |
2 | 115 | 20 | Day 3 | 2720 | 2921 | 18.7 | 94 | ND | ND | |
3 | 104 | 20 | Day 3 | 2350 | 1450 | 32.0 | 160 | 19.8 | 99 | |
4 | 158 | 20 | Day 2 | 3660 | 2868 | 32.6 | 163 | 25.2 | 126 | |
5 | 85 | 20 | None | 2090 | 2090 | 20.7 | 104 | 20.7 | 104 | |
6 | 71 | 20 | None | 1750 | 1750 | 21.5 | 108 | ND | ND | |
7 | 73 | 20 | Day 4 | 1900 | 2860 | 15.4 | 77 | 23.7 | 119 | |
8 | 90 | 20 | Day 4 | 1565 | 1243 | 23.8 | 119 | 19.0 | 95 | |
9 | 21 | 20 | Day 3 | 575 | 508 | 22.5 | 113 | ND | ND | |
10 | 228 | 20 | Day 3 | 4785 | 4071 | 23.5 | 118 | ND | ND | |
11 | 30 | 20 | Day 3 | 750 | 970 | 16.9 | 85 | 22.1 | 111 | |
12 | 56 | 20 | Days 3/5 | 1350 | 1790 | 14.8 | 74 | 19.3 | 97 | |
13 | 59 | 20 | Days 3/5 | 1475 | 1575 | 17.9 | 90 | 19.5 | 98 | |
14 | 62 | 20 | Day 4 | 1500 | 2500 | 13.0 | 65 | 22.6 | 113 | |
15 | 97 | 20 | Day 4 | 2160 | 2696 | 15.0 | 75 | 18.8 | 94 | |
16 | 101 | 20 | Day 4 | 2650 | 4070 | 13.0 | 65 | ND | ND | |
17 | 145 | 20 | Day 4 | 3400 | 2664 | 26.5 | 133 | 20.1 | 101 | |
PNET | 18 | 34 | 21 | None | 1026 | 1026 | 15.3 | 73 | ND | ND |
19 | 104 | 21 | Day 3 | 3720 | 2830 | 27.6 | 131 | ND | ND | |
20 | 74 | 21 | None | 1590 | 1590 | 16.7 | 80 | 16.7 | 80 | |
21 | 97 | 21 | Day 3 | 3141 | 2554 | 25.8 | 123 | ND | ND | |
22 | 124 | 21 | Day 3 | 3258 | 2387 | 30.7 | 146 | 20.7 | 99 | |
23 | 32 | 21 | Day 3 | 900 | 1130 | 14.5 | 69 | 19.0 | 90 | |
24 | 128 | 21 | Day 3 | 4320 | 2880 | 44.7 | 213 | ND | ND | |
25 | 74 | 21 | None | 1608 | 1608 | 21.0 | 100 | 21.0 | 100 | |
26 | 42 | 21 | None | 1020 | 1020 | 20.1 | 96 | 20.1 | 96 | |
27 | 94 | 21 | Day 3 | 3000 | 2360 | 26.7 | 127 | ND | ND | |
28 | 40 | 21 | None | 870 | 870 | 20.2 | 96 | 20.2 | 96 | |
Range: | MMT 98 | 13.0–32.6 | 65–163 | 18.8–25.2 | 94–126 | |||||
PNET | 14.5–44.7 | 69-213 | 16.7–21.0 | 80–100 |
Estimated total dose is based on the day 1 renal function-based dose without modification.
Estimated total AUC is that which would have resulted if no dose adjustment had been made (based on daily carboplatin clearance values)