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. 2007 Feb 13;96(5):725–731. doi: 10.1038/sj.bjc.6603607

Table 2. Carboplatin doses and estimated renal function-based dosing AUC vs actual AUC following pharmacologically guided dosing.

              Estimated
Achieved
Study Patient GFR (ml min−1) Target AUC (mg ml−1. min) Dose modification Estimated total dose (mg)a Actual total dose (mg) AUCb (mg ml−1.min) % target AUC AUC (mg ml−1.min) % Target AUC
MMT 98 1 110 20 Day 3 2610 1653 30.3 152 19.6 98
  2 115 20 Day 3 2720 2921 18.7 94 ND ND
  3 104 20 Day 3 2350 1450 32.0 160 19.8 99
  4 158 20 Day 2 3660 2868 32.6 163 25.2 126
  5 85 20 None 2090 2090 20.7 104 20.7 104
  6 71 20 None 1750 1750 21.5 108 ND ND
  7 73 20 Day 4 1900 2860 15.4 77 23.7 119
  8 90 20 Day 4 1565 1243 23.8 119 19.0 95
  9 21 20 Day 3 575 508 22.5 113 ND ND
  10 228 20 Day 3 4785 4071 23.5 118 ND ND
  11 30 20 Day 3 750 970 16.9 85 22.1 111
  12 56 20 Days 3/5 1350 1790 14.8 74 19.3 97
  13 59 20 Days 3/5 1475 1575 17.9 90 19.5 98
  14 62 20 Day 4 1500 2500 13.0 65 22.6 113
  15 97 20 Day 4 2160 2696 15.0 75 18.8 94
  16 101 20 Day 4 2650 4070 13.0 65 ND ND
  17 145 20 Day 4 3400 2664 26.5 133 20.1 101
PNET 18 34 21 None 1026 1026 15.3 73 ND ND
  19 104 21 Day 3 3720 2830 27.6 131 ND ND
  20 74 21 None 1590 1590 16.7 80 16.7 80
  21 97 21 Day 3 3141 2554 25.8 123 ND ND
  22 124 21 Day 3 3258 2387 30.7 146 20.7 99
  23 32 21 Day 3 900 1130 14.5 69 19.0 90
  24 128 21 Day 3 4320 2880 44.7 213 ND ND
  25 74 21 None 1608 1608 21.0 100 21.0 100
  26 42 21 None 1020 1020 20.1 96 20.1 96
  27 94 21 Day 3 3000 2360 26.7 127 ND ND
  28 40 21 None 870 870 20.2 96 20.2 96
                     
          Range: MMT 98 13.0–32.6 65–163 18.8–25.2 94–126
            PNET 14.5–44.7 69-213 16.7–21.0 80–100
a

Estimated total dose is based on the day 1 renal function-based dose without modification.

b

Estimated total AUC is that which would have resulted if no dose adjustment had been made (based on daily carboplatin clearance values)