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. 2007 Feb 13;96(5):692–700. doi: 10.1038/sj.bjc.6603568

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Copyright © 2007 Cancer Research UK

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Illustration of the St Lawrence and Lee tissue homogeneity model applied to dynamic MRI data. (A) Two-compartment model used for kinetic modelling. Following injection, CA enters the tissue capillary unit (length×) and distributes between the vascular space and the EES through a semipermeable vessel wall characterised by a permeability surface product PS. Measurement of the temporal changes in CA concentration (calculated from changes in MRI signal intensity) in both the vascular space and the EES allows to calculate the F, V_p, and PS. (B, C) Examples of contrast enhancement curves (500 images with 1.1 s temporal resolution) observed in regions of interest selected in the tumour rim (red), tumour core (blue), and normal muscle. Normal microvessels do not leak the macromolecular contrast agent. The colorectal cancer is grown subcutaneously in the left lower limb.