Table 3. Cox's univariate (HR) and multivariate (RR) analysis of the relationship between MMPs and TIMPs expression and relapse-free survival.
| Factor | No. of patients | Event frequency | HR (95% CI) | RR (95% CI) |
|---|---|---|---|---|
| MMP-1 | ||||
| Score <median vs >median | 66/62 | 29/36 | 1.6 (0.9–2.6) | — |
| Tumoural cells (−) vs (+) | 15/113 | 4/61 | 2.5 (0.9–6.9) | — |
| Fibroblasts (−) vs (+) | 27/101 | 9/56 | 2.1 (1–4.3)**** | — |
| MIC (−) vs (+) | 43/85 | 18/47 | 1.6 (0.9–2.9) | — |
| MMP-2 | ||||
| Score <median vs >median | 76/53 | 38/27 | 1 (0.6–1.7) | — |
| Tumoral cells (−) vs (+) | 86/43 | 41/24 | 1.2 (0.7–2.1) | — |
| Fibroblasts (−) vs (+) | 98/31 | 47/18 | 1.3 (0.7–2.3) | — |
| MIC (−) vs (+) | 127/2 | 69/1 | 0.8 (0.1–6.1) | — |
| MMP-7 | ||||
| Score <median vs >median | 66/61 | 37/28 | 0.8 (0.5–1.4) | — |
| Tumoural cells (−) vs (+) | 16/111 | Jun-59 | 1.6 (0.7–3.7) | — |
| Fibroblasts (−) vs (+) | 37/90 | 15/50 | 1.8 (1–3.2)*** | 1.8 (1–3.2)**** |
| MIC (−) vs (+) | 64/63 | 27/38 | 1.6 (1–2.7)*** | — |
| MMP-9 | ||||
| Score <median vs >median | 65/65 | 20/44 | 2.7 (1.6–4.7)* | 2.6 (1.5–4.5)* |
| Tumoural cells (−) vs (+) | 35/95 | 7/57 | 3.7 (1.7–8.2)* | 3.3 (1.5–7.4)** |
| Fibroblasts (−) vs (+) | 110/20 | 44/20 | 3.7 (2.2–6.4)* | 3.1 (1.8–5.3)* |
| MIC (−) vs (+) | 116/19 | 50/14 | 3.6 (2–6.8)* | 3 (1.6–5.5)* |
| MMP-11 | ||||
| Score <median vs >median | 66/63 | 24/40 | 2.1 (1.3–3.6)** | 2.5 (1.5–4.3)* |
| Tumoural cells (−) vs (+) | 15/114 | 4/60 | 2.1 (0.7–6.0) | — |
| Fibroblasts (−) vs (+) | 41/88 | 7/57 | 5.7 (2.6–12.7)* | 4.5 (2–10.1)* |
| MIC (−) vs (+) | 89/40 | 25/39 | 6.0 (3.5–10.1)* | 4.5 (2.6–7.7)* |
| MMP-13 | ||||
| Score <median vs >median | 66/65 | 35/30 | 0.7 (0.4–1.1) | — |
| Tumoural cells (−) vs (+) | 34/97 | 17/48 | 0.8 (0.5–1.5) | — |
| Fibroblasts (−) vs (+) | 67/64 | 24/41 | 2.0 (1.2–3.4)*** | 1.9 (1.1–3.2)*** |
| MIC (−) vs (+) | 87/44 | 35/30 | 2.1 (1.3–3.5)** | 2.2 (1.3–3.7)** |
| MMP-14 | ||||
| Score <median vs >median | 66/65 | 28/37 | 1.4 (0.9–2.4) | — |
| Tumoural cells (−) vs (+) | 13/118 | 5/60 | 1.4 (0.5–3.3) | — |
| Fibroblasts (−) vs (+) | 25/106 | 11/54 | 1.1 (0.6–2.2) | — |
| MIC (−) vs (+) | 64/67 | 16/49 | 4.8 (2.7–8.8)* | 4.4 (2.4–8.1)* |
| TIMP-1 | ||||
| Score <median vs >median | 65/65 | 26/38 | 2.0 (1.2–3.3)** | 1.7 (1.02–2.8)**** |
| Tumoural cells (−) vs (+) | 8/123 | 3/62 | 1.8 (0.5–5.8) | — |
| Fibroblasts (−) vs (+) | 67/64 | 36/29 | 0.8 (0.4–5.8) | — |
| MIC (−) vs (+) | 98/33 | 37/28 | 2.8 (1.7–4.6)* | 2.2 (1.3–3.7)* |
| TIMP-2 | ||||
| Score <median vs >median | 65/65 | 17/47 | 3.7 (2.1–6.5)* | 3.1 (1.7–5.5)* |
| Tumoural cells (−) vs (+) | 21/110 | 3/62 | 4.8 (1.5–15.4)*** | 3.6 (1.1–11)**** |
| Fibroblasts (−) vs (+) | 76/55 | 18/47 | 7.1 (4.0–12.5)* | 5.7 (3.2–10.1)* |
| MIC (−) vs (+) | 81/50 | 25/40 | 3.4 (2.1–5.7)* | 3.4 (2–5.7)* |
| TIMP-3 | ||||
| Score <median vs >median | 66/65 | 31/39 | 0.9 (0.6–6.5) | — |
| Tumoural cells (−) vs (+) | 18/113 | 9/56 | 1 (0.5–2) | — |
| Fibroblasts (−) vs (+) | 51/80 | 16/49 | 2.4 (1.4–4.3)** | 2 (1.1–3.7)*** |
| MIC (−) vs (+) | 62/69 | 28/37 | 1.3 (0.7–2) | — |
Abbreviations: CI=confidence interval; HR= hazard ratio; MIC=mononuclear inflammatory cells; RR= relative risk.
*P<0.001; **P<0.005; ***P<0.01; ****P<0.05.