Table 2. Molecular biomarkers analysis and correlations with PFS-6.
| N (%) | PFS-6 | P | |
|---|---|---|---|
| EGFR by FISH (n=19) | |||
| Genetic gain | 9 (47.3%) | 0 | NS |
| Disomy | 10 (52.7%) | 30% | |
| EGFR by IHC (n=21) | |||
| Positive | 8 (38.1%) | 0 | NS |
| Negative | 13 (61.9%) | 23% | |
| p-Akt by IHC (n=21) | |||
| Positive | 10 (47.6%) | 10% | NS |
| Negative | 11 (52.4%) | 18% | |
EGFR=Epidermal growth factor receptor; FISH=fluorescence in situ hybridization; IHC=immunohistochemistry; NS, nonsignificant; p-Akt=phosphorylated Akt; PFS-6=progression-free survival at 6 months.