Table 3. List of the 29 known genes located in the 5 Mb minimal region of amplification at 17q23 and their minimum, maximum and median expression levels in 26 primary breast tumours.

Gene	Description	Min	Max	Median
SEPT4	Peanut-like protein 2	ND	ND	ND
TEX14	Testis expressed sequence 14	ND	ND	ND
RAD51C	DNA repair protein RAD51 homolog	0.0	1.9	0.3
PPM1E	Protein phosphatase 1E	0.0	1.7	0.0
TRIM37	Tripartite motif-containing 37 protein	0.0	1.1	0.2
FAM33A	Family with sequence similarity 33, member A	0.0	3.3	0.3
YPEL2	Yippee-like 2 protein	0.1	1.0	0.3
DHX40	DEAH (Asp-Glu-Ala-His) box polypeptide 40	0.0	4.5	0.2
CLTC	Clathrin heavy chain 1	0.0	3.7	0.4
PTRH2	Peptidyl-tRNA hydrolase 2	0.1	14.8	1.4
TMEM49	Transmembrane protein 49	0.0	1.2	0.2
TUBD1	Tubulin δ chain	0.0	2.4	0.3
RPS6KB1	Ribosomal protein S6 kinase	0.0	1.0	0.2
ABC1	Amplified in breast cancer	0.0	1.7	0.3
CA4	Carbonic anhydrase IV precursor	ND	ND	ND
USP32	Ubiquitin C-terminal hydrolase 32	0.0	1.5	0.3
APPBP2	Amyloid β precursor protein binding protein 2	0.0	1.6	0.1
PPM1D	Protein phosphatase 2C δ isoform, magnesium-dependent	0.0	2.8	0.2
BCAS3	Breast carcinoma amplified sequence 3	0.1	2.7	0.3
TBX2	T-box transcription factor TBX2	0.0	0.7	0.1
TBX4	T-box transcription factor TBX4	0.0	9.0	0.3
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.0	2.1	0.2
THRAP1	Thyroid hormone receptor-associated protein	0.0	1.1	0.2
TLK2	Serine/threonine-protein kinase tousled-like 2	0.1	1.6	0.3
MRC2	Mannose receptor, C type 2	ND	ND	ND
CYB561	Cytochrome b561	0.3	9.2	1.3
ACE	Angiotensin-converting enzyme, somatic isoform precursor	4.0	233.0	32.1
KCNH6	Potassium voltage-gated channel, subfamily H, member 6	ND	ND	ND
WRD68	WD-repeat protein 68	0.1	1.8	0.8

ND=not determined (low or now expression in breast cancer cell lines MCF7 and BT-474 with high-level amplification).