Table 3. Set of genes found to be commonly differentially expressed in the comparison of the three ATC cell lines to normal thyroid.
| Genes | LBFC in 3ATC/NTHY |
|---|---|
| #3q | |
| Claudin 1 (CLDN1) | 19.09 |
| Butyrylcholinesterase (BCHE) | 8.59 |
| SMC4 structural maintenance of chromosomes 4-like 1 (SMC4L1) | 8.56 |
| Epithelial cell transforming sequence 2 oncogene (ECT2) | 6.85 |
| Transferrin receptor (p90, CD71) | 6.68 |
| Karyopherin α 4 (importin α 3) (KPNA4) | 4.56 |
| BM-011 protein (BM-011) | 3.18 |
| Likely ortholog of mouse IRA1 protein (IRA1) | 2.13 |
| #5 | |
| FLJ32363 protein (FLJ32363) | 3.9 |
| #7 | |
| Activator of S-phase kinase (ASK) | 8.44 |
| Zinc finger protein 92 (HTF12) | 8.01 |
| FLJ20073 protein (FLJ20073) | 7.54 |
| Asparagine synthetase (ASNS) | 6.91 |
| RB-associated KRAB repressor (RBAK) | 4.07 |
| Hypothetical protein FLJ20097 (FLJ20097) | 3.11 |
| Origin recognition complex, subunit 5-like (yeast) (ORCL5) | 2.45 |
| Paternally expressed 10 (PEG10) | 2.26 |
| #12 | |
| RAD51-interacting protein (RAD51AP1) | 5.04 |
| Forkhead box M1 (FOXM1) | 3.63 |
| Aryl hydrocarbon receptor nuclear translocator-like 2 (ARNTL2) | 2.73 |
| #14 | |
| KIAA1333 (KIAA1333) | 3.29 |
| Suppressor of Ty 16 homolog (S. cerevisiae) (SUPT16 H) | 3.25 |
| Mitogen-activated protein kinase kinase kinase kinase 5 (ASK1) | 3.23 |
| WD repeat and HMG-box DNA-binding protein 1 (WDHD1) | 2.89 |
| #18 | |
| Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) | 46.41 |
| #20 | |
| Ubiquitin-conjugating enzyme E2C (UBEC2C) | 11.92 |
| Synaptosomal-associated protein, 25 kDa (SNAP25) | 7.14 |
| Chromosome 20 open reading frame 97 (C20ORF97) | 5.75 |
| Aurora kinase A (AURKA) | 5.62 |
| Eukaryotic translation initiation factor 2, subunit 2 β, 38 kDa (EIF2S2) | 3.98 |
| Syntaxin 16 (STX16) | 3.92 |
| Chromosome 20 open reading frame 6 (C20ORF6) | 3.77 |
| CGI-09 protein (CGI-09) | 3.72 |
| TPX2, microtubule-associated protein homolog (Xenopus laevis) (TPX2) | 3.56 |
| Chromosome 20 open reading frame 100 (C20ORF100) | 2.97 |
| Phospholipase C, β 1 (phosphoinositide-specific) (PLC beta) | 2.75 |
| CSE1 chromosome segregation 1-like (yeast) (CSE1) | 2.61 |
| Solute carrier organic anion transporter family, member 4A1 (SLCO4A1) | 2.58 |
| Transglutaminase 2 (C polypeptide, protein-glutamine- γ-glutamyltransferase) (TGM2) | 2.6 |
| MCM8 minichromosome maintenance deficient 8 (S. cerevisiae) (MCM8) | 2.22 |
ATC=anaplastic thyroid carcinomas; HLA=high-level amplification regions; LBFC=lower bound of fold change.