Table 2. Germline CEB1 mutation rate in parents of childhood leukaemia cases and controls.
| Comparison | Cases | Controls | OR | 95% CI | Two-sided P* |
|---|---|---|---|---|---|
| Informative family trios (n) | 135 | 124 | |||
| Informative offspring (n) | 136 | 124 | |||
| Paternal alleles (n) | 132 | 122 | |||
| Maternal alleles (n) | 131 | 122 | |||
| Paternal germline mutations | 11 | 19 | |||
| Maternal germline mutations | 0 | 2 | |||
| Paternal mutation rate | 0.083 (8.3%) | 0.156 (15.6%) | 0.50 | 0.23–1.08 | 0.11 |
| Maternal mutation rate | 0 | 0.016 (1.6%) | 0.18 | 0.02–1.79 | 0.463 |
| Parental mutation rate | 0.041 (4.1%) | 0.086 (8.6%) | 0.47 | 0.23–0.98 | 0.061 |
CI, confidence interval; n, number; OR, odds ratio.
*Two-sided P value in Fisher's exact test.