Table 1. Details of the randomized controlled trials included in the individual patient data meta-analysis.
| Category | JFMC7-1 | JFMC15-1 | JFMC15-2 | TAC-CR | NSAS-CC | Total |
|---|---|---|---|---|---|---|
| Additional chemotherapy | Mitomycin C | Mitomycin C+FU IV | Mitomycin C+FU IV | None | None | — |
| Radiotherapy | None | None | None | None | None | — |
| UFT dose/day | 400 mg | 400 mg | 400 mg | 400 mg | 600 mga | — |
| Period | 12 months | 12 months | 12 months | 24 months | 12 months | — |
| Dates of accrual | 1986–1988 | 1989 | 1990 | 1991–1994 | 1996–2001 | — |
| No. of patients | 834 | 447 | 391 | 143 | 276 | — |
| Duration of accrual, months | 35 | 24 | 24 | 36 | 54 | — |
| Sex, No. of patients (male–female ratio) | ||||||
| Male | 521 (62.4%) | 260 (58.1%) | 244 (62.4%) | 93 (65.0%) | 167 (60.5%) | 1285 (61.4%) |
| Female | 313 (37.6%) | 187 (41.9%) | 147 (37.6%) | 50 (35.0%) | 109 (39.5%) | 806 (38.9%) |
| Duke's stage, No. of patients | ||||||
| A | 135 | 67 | 62 | 12 | 0 | 276 |
| B | 326 | 175 | 139 | 53 | 0 | 693 |
| C | 373 | 205 | 189 | 78 | 276 | 1121 |
| Median age | 57 | 60 | 59 | 62 | 58 | 58 |
| Upper age limit, years | 70 | 75 | 75 | 75 | 75 | — |
JFMC=Japanese Foundation for Multidisciplinary Treatment of Cancer; NSAS-CC=National Surgical Adjuvant Study of Colorectal Cancer; TAC–CR=Tokai Adjuvant Chemotherapy for Colorectal Cancer; UFT=Uracil–Tegafur.
a
400 mg m−2 day−1 for 5 days every 7 days.