Table 3. 10 years probability of achieving PtP among those who attempted, excluding those achieving PtP with the use of assisted reproduction techniques.

	Males N=112				Females N=90
Variable	10 years prob. of PtP (%)	95% CI	P-value (log-rank test)	P-value (Cox analysis)	10 years prob. of PtP (%)	95% CI	P-value (log-rank test)	P-value (Cox regression analysis)
All	56	47–65			59	48–69
Age at diagnosis (years)
(I) ⩽20.0	53	30–76			50	33–67	0.035 vs II 0.001 vs III
(II) 20.1–30.0	58	47–69	NS	Nsa	77	65–89	0.001 vs III	Nsa
(III) 30.1–40.0	57	35–79			18	0–41
Period of diagnosis
< 1989	43	32–55	<0.001	0.024	59	46–71	Ns	Ns
⩾1989	81	68–93			58	40–76
Stage
Stage I and II	65	54–76	0.02	Ns	64	51–77	Ns	Ns
Stage III and IV	42	27–57			50	33–67
Treatment				0.001				0.007
Rad	71	55–86	0.012 vs MedChem <0.01 vs HighChem		82	67–96	0.02 vs MedChem 0.003 vs HighChem
LowChem	85	72–98	Ns vs Rad 0.02 vs MedChem <0.001 vs HighChem		55	34–77	Ns vs Rad Ns vs MedChem 0.048 vs HighChem
MedChem	35	13–58			51	33–69
HighChem	18	4–32			27	1–54

HighChem=high gonadotoxic chemotherapy; lowChem=low gonadotoxic chemotherapy; MedChem=medium gonadotoxic chemotherapy; NS=not significant; PtP=post-treatment parenthood; Rad=Radiotherapy only

^aAge at diagnosis as continuous variable in Cox regression analysis.

Treatment: variable discriminating patients treated with radiotherapy only from those having low, medium or high gonadotoxic chemotherapy.