Table 3. Adjusted HR and 95% CI for alcohol intake and head and neck cancer.

	Head and neck cancera
	Men			Women
	Cases	HR	95% CI	Cases	HR	95% CI
Total alcohol
0 drinks per day	165	1.68	1.37–2.06	54	1.46	1.02–2.08
<1 drink per day	226	1.00	(ref)	75	1.00	(ref)
1–3 drinks per day	110	1.23	0.98–1.55	36	1.99	1.33–2.99
>3 drinks per day	110	1.48	1.15–1.90	18	2.52	1.46–4.35
P-value for trendb		0.001			0.0002
Wine c
0 drinks per day	318	1.34	1.10–1.63	91	1.58	1.12–2.25
<1 drink per day	252	1.00	(ref)	74	1.00	(ref)
1–3 drinks per day	40	1.16	0.83–1.62	18	1.97	1.17–3.31
>3 drinks per day	1	0.43	0.06–3.05	0
P-value for trendb		0.872			0.332
Beer d
0 drinks per day	230	1.18	0.96–1.45	107	0.85	0.60–1.19
<1 drink per day	286	1.00	(ref)	67	1.00	(ref)
1–3 drinks per day	41	1.24	0.89–1.72	3	0.85	0.27–2.73
>3 drinks per day	54	1.61	1.16–2.22	6	3.40	1.40–8.24
P-value for trendb		0.002			0.084
Liquor e
0 drinks per day	294	1.28	1.03–1.58	92	1.16	0.80–1.66
<1 drink per day	195	1.00	(ref)	62	1.00	(ref)
1–3 drinks per day	61	1.53	1.14–2.04	17	1.86	1.08–3.19
>3 drinks per day	61	1.85	1.37–2.50	12	2.25	1.19–4.26
P-value for trendb		<.0001			0.003

95% CI=95% confidence interval; HR=hazard ratio.

^aAdjusted for gender, age at entry into cohort, body mass index, education, smoke-quit-dose, vigorous physical activity, usual activity throughout the day, fruit intake, vegetable intake, and total energy.

^bThe test for trend was restricted to alcohol drinkers and used a linear variable where each subject was assigned the median intake value for their category.

^cAdditionally adjusted for categories of beer and liquor.

^dAdditionally adjusted for categories of liquor and wine.

^eAdditionally adjusted for categories of wine and beer.