Table 4. Adjusted HR and 95% CI for head and neck cancer subtypes by gender.

	Oral cavitya						Oropharynx and hypopharynxa						Larynxa
Cancer Sub-site	Men			Women			Men			Women			Men			Women
Gender	Cases	HR	95% CI	Cases	HR	95% CI	Cases	HR	95% CI	Cases	HR	95% CI	Cases	HR	95% CI	Cases	HR	95% CI
Total alcohol
0 drinks per day	57	1.43	1.03–2.00	24	1.24	0.74–2.10	37	2.83	1.74–4.61	9	1.50	0.63–3.58	59	1.55	1.11–2.16	15	1.39	0.71–2.74
<1 drink per day	92	1.00	(ref)	38	1.00	(ref)	30	1.00	(ref)	13	1.00	(ref)	88	1.00	(ref)	21	1.00	(ref)
1–3 drinks per day	44	1.22	0.85–1.76	15	1.74	0.95–3.20	18	1.53	0.85–2.76	10	3.24	1.40–7.52	41	1.18	0.82–1.72	9	1.56	0.71–3.43
>3 drinks per day	43	1.52	1.01–2.27	9	2.81	1.29–6.11	24	2.32	1.29–4.18	2	1.97	0.42–9.31	41	1.37	0.91–2.05	6	2.15	0.82–5.65
P-value for trendb		0.062			0.013			0.003			0.132			0.095			0.042
Wine c
0 drinks per day	120	1.46	1.07–1.99	40	1.43	0.86–2.39	60	1.39	0.87–2.24	17	1.87	0.83–4.23	121	1.27	0.93–1.74	26	1.34	0.70–2.56
<1 drink per day	102	1.00	(ref)	37	1.00	(ref)	38	1.00	(ref)	13	1.00	(ref)	95	1.00	(ref)	21	1.00	(ref)
1–3 drinks per day	14	0.97	0.55–1.70	9	2.07	0.99–4.34	10	1.98	0.98–4.00	4	2.28	0.74–7.09	13	1.03	0.58–1.84	4	1.56	0.53–4.59
>3 drinks per day	0			0			1	2.59	0.35–19.05	0			0			0
P-value for trendb		0.401			0.451			0.093			0.400			0.530			0.789
Beer d
0 drinks per day	79	0.95	0.68–1.34	49	0.83	0.50–1.35	52	2.52	1.53–4.17	17	0.49	0.22–1.07	83	1.00	0.72–1.39	34	1.39	0.71–2.71
<1 drink per day	117	1.00	(ref)	32	1.00	(ref)	36	1.00	(ref)	16	1.00	(ref)	115	1.00	(ref)	14	1.00	(ref)
1–3 drinks per day	17	1.30	0.78–2.18	1	0.67	0.09–4.97	8	1.83	0.85–3.97	1	1.14	0.15–8.86	14	1.01	0.58–1.77	1	1.17	0.15–9.01
>3 drinks per day	23	1.78	1.08–2.94	4	5.96	1.94–18.30	13	3.12	1.54–6.31	0			17	1.14	0.65–1.98	2	3.76	0.78–18.23
P-value for trendb		0.016			0.092			0.0003			0.517			0.772			0.122
Liquor e
0 drinks per day	109	1.20	0.86–1.68	42	1.04	0.62–1.75	53	1.16	0.68–1.96	19	2.23	0.90–5.51	114	1.49	1.06–2.10	24	0.87	0.40–1.68
<1 drink per day	81	1.00	(ref)	32	1.00	(ref)	29	1.00	(ref)	8	1.00	(ref)	71	1.00	(ref)	20	1.00	(ref)
1–3 drinks per day	25	1.56	0.99–2.45	6	1.35	0.56–3.26	14	2.36	1.24–4.49	5	4.28	1.38–13.27	19	1.27	0.77–2.12	4	1.17	0.40–3.44
>3 drinks per day	21	1.65	1.00–2.72	6	2.45	0.99–6.05	13	2.52	1.28–4.99	2	3.28	0.66–16.27	25	1.99	1.24–3.21	3	1.31	0.38–4.57
P-value for trendb		0.068			0.072			0.009			0.135			0.001			0.298

95% CI=95% confidence interval; HR=hazard ratio.

^aAdjusted for gender, age at entry into cohort, body mass index, education, smoke-quit-dose, vigorous physical activity, activity throughout the day, fruit intake, vegetable intake, and total energy.

^bThe test for trend was restricted to alcohol drinkers and used a linear variable where each subject was assigned the median intake value for their category.

^cAdditionally adjusted for categories of beer and liquor.

^dAdditionally adjusted for categories of liquor and wine.

^eAdditionally adjusted for categories of wine and beer.