Table 2. Analysis of DFS and OS in relation to clinicopathological parameters, p53, BAX and Bcl-2 protein expression and MSI status.
| n | 5-year DFS (%) | P | 5-year OS (%) | P | |
|---|---|---|---|---|---|
| Sex | |||||
| Male | 79 | 57.1 | 0.2 | 68.8 | 0.3 |
| Female | 109 | 65.7 | 70.7 | ||
| Age, years | |||||
| ⩽62 | 98 | 64.7 | 0.6 | 72.7 | 0.4 |
| >62 | 90 | 59.4 | 66.8 | ||
| T category, pathologic | |||||
| T2 | 19 | 83.9 | 0.05 | 83.9 | 0.1 |
| T3–4 | 169 | 59.7 | 68.3 | ||
| N category, pathologic | |||||
| N1 | 107 | 71.6 | 0.001 | 80.2 | 0.0001 |
| N2–3 | 81 | 49.3 | 55.7 | ||
| Differentiation | |||||
| G1–2 | 138 | 66.8 | 0.005 | 74.9 | 0.003 |
| G3–4 | 50 | 49.3 | 55.6 | ||
| Location | |||||
| Right | 93 | 66.9 | 0.1 | 74.2 | 0.3 |
| Left | 95 | 57.1 | 65.5 | ||
| Treatment arm | |||||
| Arm A (5-FU/LV) | 95 | 70.5 | 0.01 | 76.7 | 0.02 |
| Arm B (5-FU/LEV) | 93 | 53.2 | 62.4 | ||
| BAX staining index | |||||
| High | 111 | 71.7 | 0.0005 | 76.1 | 0.002 |
| Low | 77 | 48.2 | 60.7 | ||
| Bcl-2 expression | |||||
| Positive | 131 | 59.9 | 0.7 | 69.3 | 0.7 |
| Negative | 57 | 67.5 | 71.3 | ||
| p53 expression | |||||
| Positive | 94 | 57 | 0.2 | 67.3 | 0.2 |
| Negative | 94 | 67.3 | 72.6 | ||
| MSI status | |||||
| MSI− | 158 | 59.4 | 0.5 | 68 | 0.4 |
| MSI+ | 16 | 67.5 | 81.3 | ||
Kaplan–Meier curves compared by log-rank test.
DFS=disease-free survival; MSI=microsatellite instability; OS=overall survival. Bold values signify P<0.05.