Table 4. Multivariate analysis of clinicopathological and genetic parameters for DFS (Cox regression hazard analysis).
|
DFS
|
|||
|---|---|---|---|
| Prognostic factor | P-values | Hazard ratio | 95% CI |
| Step 1 | |||
| pT category | |||
| T3/4 | 0.11 | 2.6 | 0.8–8.3 |
| pN category | |||
| N2/3 | 0.008 | 1.9 | 1.2–3.1 |
| Differentiation | |||
| G3/4 | 0.22 | 1.4 | 0.8–2.3 |
| Treatment arm | |||
| Arm B (5-FU/LEV) | 0.01 | 1.9 | 1.2–3.0 |
| BSI | |||
| Low | 0.001 | 2.2 | 1.4–3.6 |
| Step 2 | |||
| pT category | |||
| T3/T4 | 0.09 | 2.7 | 0.9–8.7 |
| pN category | |||
| N2/3 | 0.005 | 2 | 1.2–3.2 |
| BSI | |||
| Low | 0.001 | 2.3 | 1.4–3.7 |
| Treatment arm | |||
| Arm B (5-FU/LEV) | 0.008 | 1.9 | 1.2–3.1 |
CI=confidence interval; DFS=disease-free survival; 5-FU=5-fluorouracil; LEV=levamisole. Bold values signify P<0.05.