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. 2007 Apr 10;96(9):1358–1367. doi: 10.1038/sj.bjc.6603726

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Copyright © 2007 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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Combination index (CI) plots of PMX/GEM, PMX/DCT and PMX/CPT-11 association in MIA PaCa2, CFPAC-1 and Capan-1 pancreatic cancer cell lines. Data are represented as concentration/combination index (CI) plot. The CI was calculated in a constant ratio combination experimental design. The 1 : 1 and 10 : 1 concentration ratio of PMX/GEM, PMX/DCT and PMX/CPT-11 combinations were represented. CI<1 (green colour), CI=1 and CI>1(red colour) indicate synergistic, additive and antagonistic effects, respectively. Dotted lines: C_max of GEM, DCT, CPT-11 and PMX. The plots represent the mean of six experiments.