Table 5. Multivariate analyses for the prediction of clinico-pathological parameters by immunostaining results of MYC, BARK1, PP1α, PP2A, NM23-H1 and FASN.
| Clinico-pathological factor | Cases in analysis | Resultsa | P-valueb | OR (95% CI) |
|---|---|---|---|---|
| Gleason score (Gs2-6/Gs7-9) | 82 | MYC | <0.001 | 7.143 (2.079–24.390) |
| BARK1 | 0.023 | —c | ||
| FASN | 0.036 | 3.106 (1.035–9.259) | ||
| pT-stage (pT2/pT3-pT4) | 77 | MYC | <0.001 | 6.993 (2.387–20.408) |
BARK1=β-adrenergic receptor kinase 1; FASN=Fatty acid synthase; PP2A=protein phosphatases.
a
Results of logistic regression analysis with a moderate backward selection.
b
P-value of likelyhood-ratio test.
c
Numerically not computable as each of the eight negative BARK1 staining results was exclusively found in advanced Gleason scores (Gs7–9) (see Table 4).