Figure 1.

The effect of γ-inulin and zymosan on PDT response of B16BL6 tumours. Subcutaneously growing tumours were treated by PDT (BPD 2.5 mg ml⁻¹ i.v. followed 3 h later by 100 J cm⁻² of 690±10 nm light). Zymosan (0.5 mg mouse⁻¹) and γ-inulin (0.1 mg mouse⁻¹ except with one treatment group that received 0.2 mg mouse⁻¹) were administered by intratumoural injection immediately after PDT light treatment, whereas IFN-γ (3 × 10⁴ U mouse⁻¹) was given peritumourally at 24 h before PDT light. All treated tumours showed initially a complete response followed by the recurrence after time intervals that varied with different treatment groups (presented in the ordinate as average time for tumour recurrence). There was one cured tumour in PDT+IFN-γ+γ-inulin group (which translates into 12.5% cure rate); for including it into the recurrence time calculation, it was assigned time of 55 days. N=8; bars are s.d. ^*Statistically significant difference compared to PDT only group.