Table 1. HIF-1α expression in the gastric cancer progression sequence.
|
HIF-1α density
|
HIF-1α intensity
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Biopsy type | n | 0% | <2% | 2–10% | 11–30% | >30% | Weak | Mod | Strong |
| Normal mucosa | 20 | 20 | — | — | — | — | — | — | — |
| H. pylori gastritis | 24a | 12 | 12 | — | — | — | 11 | 1 | — |
| Intestinal metaplasia | 24a | 14 | 8 | 2 | — | — | 7 | 3 | — |
| Dysplasia | 12 | 6 | 2 | 3 | 1 | — | 1 | 2 | 3 |
| Intestinal type adeno | 19 | 3 | 7 | 5 | 3 | 1 | 6 | 2 | 8 |
| Diffuse type adeno | 21 | 11 | 3 | 2 | 2 | 3 | 1 | 0 | 9 |
Abbreviation: HIF=hypoxia inducible factor.
a
Four biopsies had areas of H. pylori gastritis and intestinal metasplasia and were included in both subcategories.
The increases in HIF-1α density (P=0.0001) and intensity (P=0.0001) were highly statistically significant (Jonckheere–Terpstra test).