Table 2. Distribution of 176a patients according to tumour HIF-1α expression.

	HIF-1α expression
Factor	Negative	Positive	P *
Differentiation
Well	12	6
Mod	33	34
Poor	38	53	0.14
Lauren type
Diffuse	41	50
Intestinal	42	43	0.56
T stage
T in situ	2	1
T1	6	10
T2	29	25
T3	43	56
T4	3	1	0.44
N stage
N0	23	29
N1	51	49
N2	7	13
N3	2	2	0.58
M stage
M0	81	91
M1	2	2	0.91
Overall TNM stage
0	2	1
I	11	20
II	33	21
III	31	48
IV	6	3	0.045

Abbreviations: HIF=hypoxia inducible factor; TNM=tumour node metastasis.

^aOne patient with a missing slide was excluded.

^*χ² P-value.