Table 4. Univariate survival analysis of putative prognostic factors following surgical resection for gastric and gastro-oesophageal cancer.
|
Overall survival
|
Cancer-specific survival
|
|||||
|---|---|---|---|---|---|---|
| Parameter | HR | 95% CI | P * | HR | 95% CI | P * |
| HIF | ||||||
| 0 | 1 | — | — | 1 | — | |
| 1/2/3/4 | 1.1 | 0.8–1.4 | 0.62 | 1.0 | 0.7–1.5 | 0.82 |
| HIF | ||||||
| Negative | 1 | — | — | 1 | — | — |
| Focal | 0.9 | 0.5–1.3 | 0.49 | 0.7 | 0.5–1.2 | 0.26 |
| Invasive edge | 1.6 | 1.0–2.4 | 0.042 | 1.6 | 1.0–2.5 | 0.047 |
| Diff | ||||||
| Well | 1 | — | — | 1 | — | — |
| Mod | 2.9 | 1.4–6.2 | 0.005 | 3.4 | 1.3–8.5 | 0.011 |
| Poor | 3.7 | 1.8–7.8 | 0.001 | 5.3 | 2.1–13.3 | 0.001 |
| Lauren type | ||||||
| Intestinal | 1 | — | — | 1 | — | — |
| Diffuse | 1.4 | 1.0–2.0 | 0.052 | 1.8 | 1.2–2.6 | 0.003 |
| Location | ||||||
| Non-GOJ | 1 | — | — | 1 | — | — |
| GOJ | 1.4 | 1.0–2.0 | 0.083 | 1.5 | 1.0–2.2 | 0.059 |
| T stage | ||||||
| T0/1 | 1 | — | — | 1 | — | — |
| T2 | 2.6 | 1.0–6.7 | 0.052 | 5.2 | 1.2–22.0 | 0.023 |
| T3 | 4.8 | 1.9–12.0 | 0.001 | 9.6 | 2.3–39.0 | 0.002 |
| T4 | 16.8 | 4.4–64.2 | 0.0001 | 37.5 | 6.8–207.6 | 0.0001 |
| N stage | ||||||
| N0 | 1 | — | — | 1 | — | — |
| N1 | 2.0 | 1.3–3.0 | 0.003 | 2.5 | 1.5–4.1 | 0.001 |
| N2 | 3.5 | 1.9–6.4 | 0.0001 | 4.8 | 2.5–9.2 | 0.0001 |
| N3 | 4.2 | 1.5–12.0 | 0.008 | 5.7 | 1.9–16.9 | 0.002 |
| M stage | ||||||
| M0 | 1 | — | — | 1 | — | — |
| M1 | 2.6 | 1.0–7.1 | 0.062 | 2.9 | 1.1–7.9 | 0.037 |
| Overall TNM stage | ||||||
| 0/1 | 1 | — | — | 1 | — | — |
| 2 | 1.4 | 0.8–2.6 | 0.25 | 1.8 | 0.9–3.6 | 0.12 |
| 3 | 3.3 | 1.9–5.9 | 0.0001 | 4.5 | 2.3–8.8 | 0.0001 |
| 4 | 7.6 | 3.3–17.5 | 0.0001 | 10.9 | 4.4–27.1 | 0.0001 |
| R class | ||||||
| R0 | 1 | — | — | 1 | — | — |
| R1 | 2.3 | 1.6–3.3 | 0.0001 | 2.7 | 1.8–4.0 | 0.0001 |
| R2 | 5.8 | 2.9–11.6 | 0.0001 | 7.2 | 3.6–14.5 | 0.0001 |
Abbreviations: CI=confidence interval; HR=hazard ratio; TNM=tumour node metastasis. *Obtained using a univariate Cox-proportional hazards model.