Table 1. The OSCC cell lines and the status of Bmi-1, p16^INK4A, p53, and HPV infection.

Cells	Tissue origin	Bmi-1a	p16INK4Ab	p53	HPV status
BaP-Tc	gingiva	−	+	Targeted by E6	+/type 16
SCC4d	tongue	+	+	mutant	−
SCC9d	tongue	+	−	−	−
SCC15d	tongue	+	−	−	−
HEp-2d	larynx	+	+	Targeted by E6	+/type 18
1483e	oral	+	+	Targeted by E6	+/type 18
FaDud	pharynx	+	+	Mutant	−
Tu139f	larynx	+	−	Mutant	−
RKOg	colorectum	+	−	wild-type	−
HeLad	cervix	+	+	Targeted by E6	+/type 18

^aBmi-1 overexpression was determined based on the RT–PCR and Western blotting results (Figure 1). Positive indicates enhanced expression compared with the baseline (negative) expression level found in the NHOK cultures.

^bp16^INK4A expression status is based on the Western blotting results (Figure 1B).

^cTumourigenic counterpart of NHOK (Park et al, 1995).

^dPurchased from American Type Culture Collection. The protein expression patterns for these cell lines were based on Munro et al, 1999.

^eGift of P. Sacks (Univ. Texas, Houston, TX, USA).

^fGift of G. Clayman (Univ. Texas, Houston, TX, USA).

^gGift of M. Kastan (Johns Hopkins, Baltimore, MD, USA).