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. 2007 Oct 30;97(10):1449–1456. doi: 10.1038/sj.bjc.6604056

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Copyright © 2007 Cancer Research UK

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Schematic representation of folate metabolism. Corresponding enzymes for genes with polymorphisms investigated in this study are boxed. B vitamin cofactors are in ovals. TS, thymidylate synthase; MTHFR, methylenetetrahydrofolate reductase; MTR, methionine synthase; MTRR methionine synthase reductase; THF, tetrahydrofolate; DHF, dihydrofolate; dUMP, deoxyuridine monophosphate; dTMP, deoxythymidine monophoshate; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine.