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. 2007 Oct 30;97(10):1449–1456. doi: 10.1038/sj.bjc.6604056

Table 3. Association of TS 1494del6 and MTHFR C677T genotypes and colorectal adenoma risk stratified by nutrient intake.

  Genotype
 
  TS1494del6
 
Tertiles of nutrient intake from food onlya Ins/ins Ins/del Del/del P interaction
Folate
 High
  No. of cases/controls 63/54 49/23 5/14  
  OR (95% CI)b Ref 1.82 (0.96–3.49) 0.30 (0.10–0.95)  
         
 Low/medium
  No. of cases/controls 240/81 189/85 37/20  
  OR (95% CI)b 1.53 (0.89–2.64) 1.13 (0.65–1.95) 1.19 (0.51–2.75) 0.01
         
Vitamin B2
 High
  No. of cases/controls 84/49 52/33 7/10  
  OR (95% CI)b Ref 1.00 (0.56–1.80) 0.35 (0.12–1.01)  
         
 Low/medium
  No. of cases/controls 219/86 186/75 35/24  
  OR (95% CI)b 1.05 (0.66–1.69) 1.07 (0.66–1.73) 0.55 (0.26–1.17) 0.86
         
Vitamin B6
 High
  No. of cases/controls 59/53 57/25 8/13  
  OR (95% CI)b Ref 2.26 (1.21–4.23) 0.52 (0.20–1.41)  
         
 Low/medium
  No. of cases/controls 244/82 181/83 34/21  
  OR (95% CI)b 1.54 (0.90–2.65) 1.09 (0.61–1.94) 1.46 (0.46–4.59) 0.006
         
Vitamin B12
 High
  No. of cases/controls 87/43 61/29 9/19  
  OR (95% CI)b Ref 1.23 (0.67–2.29) 0.25 (0.10–0.63)  
         
 Low/medium
  No. of cases/controls 216/92 177/79 33/15  
  OR (95% CI)b 1.39 (0.86–2.24) 1.00 (0.62–1.62) 1.00 (0.45–2.22) 0.03
         
Alcohol
 Low
  No. of cases/controls 94/40 77/47 8/13  
  OR (95% CI)b Ref 0.61 (0.35–1.05) 0.23 (0.08–0.71)  
         
 High/medium
  No. of cases/controls 243/103 211/72 40/26  
  OR (95%CI)b 0.89 (0.55–1.42) 1.04 (0.63–1.73) 0.57 (0.28–1.14) 0.11
Folate
 High
  No. of cases/controls 51/37 47/46 19/8  
  OR (95% CI)b Ref 0.71 (0.38–1.34) 1.79 (0.67–4.78)  
         
 Low/medium
  No. of cases/controls 214/93 201/79 51/14 0.59
  OR (95% CI)b 1.44 (0.81–2.57) 1.37 (0.76–2.48) 2.28 (0.94–5.57)  
         
Alcohol
 Low
  No. of cases/controls 81/53 79/40 19/7  
  OR (95% CI)b Ref 1.29 (0.74–2.24) 1.67 (0.63–4.46)  
         
 High/medium
  No. of cases/controls 225/90 210/93 59/18  
  OR (95% CI)b 1.47 (0.92–2.33) 1.30 (0.80–2.09) 2.41 (1.21–4.83) 0.44
a

Cut points for tertiles of dietary intakes: folate (μg day−1) 295/383; vitamin B2 (mg day−1) 2.29/2.84; vitamin B6 (mg day−1) 2.18/2.71; vitamin B12 (μg day−1) 5.30/7.65, alcohol (units per week) men 3/15, women 1/8.

b

Odds ratios and 95% confidence intervals adjusted for sex, smoking, alcohol consumption, and dietary intakes of fibre, folate, and vitamins B2 and B6 (from food and supplements) where appropriate.