Table 4. Association of TS and MTHFR haplotypes and colorectal adenoma risk.

Gene	Haplotype	Frequency (%)	No. of case/control	OR (95% CI)a
TS	3R/ins	28.6	384/169	Ref
	2R/ins	41.7	572/236	1.02 (0.79–1.31)
	3R/del	25.5	328/166	0.80 (0.61–1.07)
	2R/del	4.2	52/29	0.84 (0.49–1.45)
MTHFR	677C/1298A	36.4	494/215	Ref
	677T/1298A	32.2	445/183	0.92 (0.66–1.29)
	677C/1298C	31.4	407/204	0.85 (0.66–1.09)

^aOdds ratios and 95% confidence intervals adjusted for sex, smoking, alcohol consumption, and dietary intakes of fibre, folate, and vitamins B₂ and B₆ (from food and supplements).