Table 1. Dose escalation and dose limiting toxicity.

Dose level	Pertuzumab (mg)	Docetaxel (mg m−2)	Number of patients planned (treated)	Number of patients with DLT
Initial dose escalation schedule
1	1050	60	3–6 (6)	0
2	1050	75	6 (2)	2
3	1050	100	6 (0)	—
Amended dose escalation schedule:
1A	840/420	60	—	—
2A	840/420	75	6 (6)	0
3A	840/420	100	6 (5)	2