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. 2007 Oct 30;97(11):1523–1531. doi: 10.1038/sj.bjc.6604057

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Copyright © 2007 Cancer Research UK

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Effect of morphine and co-administration of celecoxib on survival and pain behaviour in SCK tumour-bearing mice. (A) Kaplan–Meier plot for survival of SCK tumour-bearing mice after treatment with morphine and co-administration with celecoxib for 13 days (after 14 days of tumour cell injection). Note, celecoxib alone led to mortality starting at day 4, whereas morphine treatment resulted in highest mortality, which occurred on day 14. Co-administration of both showed highest percent of surviving mice on day 14. n=20 mice/treatment. (B) Behavioural analysis performed for thermal hyperalgesia using Hargreave's apparatus. Right paw of the tumour-bearing leg was tested on each mouse three times at 10 min intervals for PWL. Decrease in duration of heat tolerance shows an increase in thermal perception of pain. Overall, pain increases with time during tumour growth in control as well as morphine- or celecoxib-treated mice. Co-administration of morphine and celecoxib shows the highest heat tolerance or least perception of thermal stimuli. Data are shown as mean±s.d. n=6–20.