Table 2. Effect of morphine treatment on survival following high-dose celecoxib treatment.

	Percent of surviving mice after treatment
Treatment type	After day 1	After day 2	After day 10
(i) Vehicle control	100	100	100
(ii) Morphine	100	100	100
(iii) Celecoxib	50	0	—
(iv) Morphine+celecoxib	100	100	100a

After 24 h of SCK tumour cell injection, mice were treated with (a) vehicle control, 50 μl normal saline+50 μl 0.5% methylcellulose; (b) morphine, 0.714 mg per kg mouse per day (equivalent to 50 mg morphine per day per 70 kg human adult) during the first week, followed by 1 mg per kg mouse per day, thereafter; (c) 100 mg celecoxib per kg mouse per day for 1 day; and (d) morphine as described in (b) and celecoxib.

^a100 mg per kg mouse per day for one day followed by 30 mg per kg per day.